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KMID : 0378019940370100042
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New Medical Journal
1994 Volume.37 No. 10 p.42 ~ p.48
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Ultrastructural Studies on o, p´-DDD Induced Nephrotoxicity in Rats
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Abstract
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o,p’-DDD, a derivative of insecticide DDT, which reveals the toxicity and adrenostatic effect by cortisol biosynthesis in the zona fasciculata of adrenal cortex has been used for the treatment of unoperable adrenocortical carcinoma. Adverse effects of o,p´-DDD were usually dose-related and reversibly. Most untoward effects include gastrointestinal disturbances, neuromuscular disorders, depression of central nervous system and skin rash but there is a few reports on its nephrotoxcities. o,p’-DDD in corn oil was administered orally to rats for 28 days to investigate its nephrotoxicity by observation of the ultrastructural changes in renal glomeruli.
The results obtained were as follows.
1. The ultimate destructive target of intracytoplasmic organelle in endothelium and of renal glomeruli was mitochondria. The severity of the mitochondrial alterations was dependent of the dosages of o, p’ -DDD,
2. The characteristic ultrastructural changes in endothelium of glomerular capillary were swelling and detachment from underlying basement membrane. The splitting and complete separations between endothelium and basement membrane were observed in more advanced lesions by the increased dosage of administration of o,p´ -DDD and basement membrane in capillary wall of renal glomeruli was irregular and partly thickened.
3. Amorphous double ring formation, electron dense deposits and multiple myelin figures in mitochondria were characteristic ultrastructural findings in the epithelium of glomeruli.
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